Maternal Cannabis Use During Pregnancy and Maternal and Neonatal Outcomes: A Retrospective Cohort Study

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Results
Rates of reported cannabis use in pregnancy increased from 1.3% to 7.5% over the study period with no appreciable change in slope after legalisation in 2018. Infants of mothers reporting cannabis use in pregnancy were more likely to have major anomalies and a 5-minute Apgar score ≤ 7, require NICU admission, and had lower birth weight, head circumference, and birth length than infants of mothers not reporting cannabis use. These associations did not differ before and after legalisation.

Conclusions
Reported cannabis use during pregnancy is associated with early postnatal complications and reduced fetal growth, even after taking into account a range of confounding factors. Rates of reported cannabis use during pregnancy increased over the past five years in Nova Scotia with no apparent additional effect of legalisation.