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The advisory mentions the following risks:
1. Marijuana is addictive. Approximately one in eleven individuals who use marijuana will become addicted. The risk is greater in youth. One in six teenagers who use marijuana will become addicted, and the risk for developing a marijuana substance use disorder further increases for those who use marijuana frequently.....

• Marijuana is addictive. Approximately one in 11 adults who use marijuana will become addicted, and the risk of addiction is greater among youth.  
• ... Read More

When mothers use marijuana during the first 12 years of their child's life, their cannabis-using children are more likely to start at an earlier age than children of non-using mothers, according to a new study from the Harvard T.H. Chan School of Public Health published in the American Journal of Preventive Medicine. This study is the first to establish a relationship between maternal cannabis use during a child's lifetime and earlier initiation in a nationally-... Read More

There was more alarming news. Use of illegal drugs, including cocaine, marijuana, and opioids by pregnant women increased significantly between 2015 and 2017. About 7 percent of pregnant women reported using marijuana. Three... Read More

In conclusion, cannabis use is common in people with chronic non-cancer pain who have been prescribed opioids, and interest in medicinal use of cannabis is increasing. We found no evidence that cannabis use improved patient outcomes; those who used cannabis had greater pain and lower self-efficacy in managing pain. Furthermore, we found no evidence that cannabis use reduced pain interference or exerted an opioidsparing effect.

Over the past several years, FDA has issued several warning letters to firms that market unapproved new drugs that allegedly contain cannabidiol (CBD). As part of these actions, FDA has tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD they claimed to contain. It is important to note that these products are not approved by FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease.... Read More

The importance of the published findings and the emerging research regarding the potential negative effects of marijuana on brain development are a cause for concern despite the limited research and are the basis for the following recommendations:

1. Women who are considering becoming pregnant or who are of reproductive age need to be informed about the lack of definitive research and counseled about the current concerns regarding... Read More

During the same time period that cigarette smoking around children came down more than 7%, marijuana smoking around children went up nearly 5%. With more and more states legalizing marijuana for recreational use, that number is likely to continue going up.
This is not good. Besides the fact that we don’t want children getting high, or exposed to the dangers of inhaled secondhand marijuana smoke, there is the additional concern about long-term effects on the brain. While research is... Read More

When we talk about legalizing marijuana, we must acknowledge that we are talking about legalizing a mind-altering substance that affects the brain by impairing cognition, judgment, and reflexes. We need to discuss the science and data behind the consequences of marijuana consumption on our youth and their developing brains, as this is an issue that is far-too-often overlooked.

Teens have taken a technology that was supposed to help grownups stop smoking and invented a new kind of bad habit, molded in their own image.

“Juul is... Read More

"Marijuana doctors were 2.8 times as likely as other doctors to have been disciplined by the Board of Medicine, and 2.4 times as likely to have been charged with a crime. Altogether, 108 of them were responsible for $69.4 million in malpractice judgments and settlements, some for maiming or killing patients. Some of the doctors have been fined, suspended or stripped of their licenses in other states. They’ve misdiagnosed conditions, falsified records and... Read More

Researchers had two women conduct "mystery caller" phone conversations with employees at 400 dispensaries across the state, telling them that they were eight weeks pregnant and suffering from morning sickness. During the majority of those calls, the employees recommended the women use cannabis products.

I'm here to tell you this is not a safe drug," McCance-Katz said during a town hall event at "NatCon18," the National Council for Behavioral Health's annual conference.
"Americans have a right to know that and we should be telling them that," she continued.
And while tobacco and alcohol rates have declined among pregnant women in recent years, illicit drugs -- mainly marijuana but also opioids -- have... Read More

(TIME)  April 20, also known as “420,” is a day popular with many marijuanasmokers who see it as a “national holiday” of sorts and celebrate by getting high. The term “420” originated in the 1970s with a group of California high schoolers who would regularly meet after school at 4:20 p.m. to smoke weed.
 

Conclusions: Our findings disconfirm the hypothesis that a population-level negative correlation between medical marijuana use and prescription drug harms occurs because medical marijuana users are less likely to use prescription drugs, either medically or nonmedically. Medical marijuana users should be a target population in efforts to combat nonmedical prescription drug use.

From 2005 to 2015, 4,202 marijuana-related visits were identified. Behavioral health evaluation was obtained for 2,813 (67%); a psychiatric diagnosis was made for the majority (71%) of these visits. Coingestants were common; the most common was ethanol (12%). Marijuana-related visits increased from 1.8 per 1,000 visits in 2009 to 4.9 in 2015. (p = < .0001) CONCLUSIONS: Despite national survey data suggesting no appreciable difference in adolescent marijuana use, our data demonstrate... Read More

1. Legalizing cannabis has been shown to increase the rates of motor vehicle accidents.
2. Cannabis use is a risk factor for mental illness.
3. Inhaled Cannabis use is a risk factor for respiratory infections.
4. Cannabis use increases the rate of vascular disease. Cannabis is the third most often identified drug of abuse
5. Cannabis use during pregnancy has been associated with increased risk of adverse birth outcomes
6. Legalization of cannabis has been shown... Read More

It is a sham that expands the conditions that qualify an individual for “medical marijuana” to any condition and for any person, no matter of age. It is a scheme to establish a system of “fake” medicine to further the game plan of the marijuana industry for full commercialism that will allow anyone for any reason to buy marijuana for the high they desire and the profit the industry demands. It is now up to the Vermont House to recognize what is happening and stop it before it is too late.... Read More

Overall, while less dangerous than opioids by far, and possibly helpful for some conditions, including pain, no findings, to my knowledge, clearly demonstrate that marijuana use positively impacts people with opioid use disorder. Moreover, marijuana use carries risks, including cannabis use disorder, psychosis and cognitive impairment, as well as additive effects when used with other substances, including opioids.

Kara Macek, spokeswoman for the GHSA, said the organization could point to several possible factors in the high level of fatalities: increased exposure to danger as more drivers hit the road and more people move to urbanized areas, an uptick in distracted driving from cellphone use, or even an increase in accidents in states that have legalized recreational marijuana use.
The GHSA report noted that in some states that have legalized recreational marijuana — Alaska, Colorado, Maine,... Read More

Marijuana use is associated with an increased risk of prescription opioid use.  
Marijuana use seems to strengthen the relationship between pain and depression and anxiety, not ease it.

"Every person I've ever asked that has a drug addiction problem, I would ask them intentionally 'what was your drug of choice that set you on this path?' Marijuana. Every time, marijuana," Judd said.
He went on to say that when you look at all the drugs killing people and contributing to drug related deaths, "leaving marijuana out of the recipe would be a horrible mistake."

“The violence is there with other drugs, but we don’t see the homicides associated with other narcotics as we do with marijuana,” said Anoka County Sheriff’s Lt. Wayne Heath, commander of the Anoka-Hennepin Narcotics and Violent Crimes Task Force. “No one knows why in marijuana it leads to that extra step.”

An 11-month-old Colorado boy’s death from a heart condition was likely related to ingestion of marijuana, two Denver doctors have concluded, but the precise link remains unclear.

Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency.
Cryptococcal meningitis is a life-threatening condition most commonly observed in immunocompromised individuals. We describe a daily cannabis smoker without evidence of immunodeficiency presenting with confirmed Cryptococcus neoformans meningitis. An investigation of cannabis samples from the patient's preferred dispensary demonstrated contamination with several varieties... Read More

New research reveals that several species, including the northern spotted owl, are succumbing to rat poison from thousands of "unpermitted private marijuana grow sites" in the northwestern California counties of Humboldt, Mendocino and Del Norte.
It's the contamination of the owls' primary food source — mice and rats, which, like humans, are attracted to the aromatic crop — that has been the animals' undoing... Read More

“Every statistical study has seen an increase in marijuana use,” he said. “There has been an increase in youths going to rehab for addiction to marijuana. There have been increases in car accidents. There has been an increase in fatalities related to marijuana. There has been an increase in workplace incidences related to marijuana and a decrease in productivity. And there has been an increase in robberies.”
“There has been nothing good for Colorado, except for maybe the increased tax... Read More

A team of law enforcement agents from the U.S. Forest Service, local police and the U.S. Fish and Wildlife Service hike deep into the Plumas National Forest to help with cleanup and protect scientists who are studying illegal marijuana grow sites. Even after a site has been raided, growers can return. The nets are for helicopters that will lift tons of garbage out of the site. On this reclamation trip, teams ultimately cleaned up about 7 tons of garbage, 4,000 pounds of fertilize, and 4... Read More

But she didn't have cancer. She had an obscure syndrome called cannabinoid hyperemesis syndrome, a condition only recently acknowledged by the medical community. It affects a small population — namely, a subset of marijuana users who smoke multiple times a day for months, years or even decades.

There's no hard data on the prevalence of the illness. But in California and Colorado, which have loosened marijuana laws in recent years, some emergency physicians say they're... Read More

DENVER (CBS4) – Denver police have made at least 12 arrests after a year-long investigation into the Sweet Leaf marijuana dispensaries in the Mile High City.  Investigators accuse Sweet Leaf of selling amounts of marijuana that exceed the Amendment 64 regulations of no more than an ounce of the drug per sale.

Marijuana has both short- and long-term effects on the body.
Within a few minutes of smoking marijuana, a person feels the effects of pot, as THC is rapidly passes from the lungs into the bloodstream, making its way to the brain and other organs.
What causes the “high” people experience is marijuana’s effect on over-activating parts of the brain containing specific brain cell receptors. This leads to feelings of an altered sense of time, other altered senses, changes in mood,... Read More

WASHINGTON - The Department of Justice today issued a memo on federal marijuana enforcement policy announcing a return to the rule of law and the rescission of previous guidance documents. Since the passage of the Controlled Substances Act (CSA) in 1970, Congress has generally prohibited the cultivation, distribution, and possession of marijuana.
In the memorandum, Attorney General Jeff Sessions directs all U.S. Attorneys to enforce the laws enacted by Congress and to follow well-... Read More

RESULTS:
Alcohol/cigarettes followed by marijuana was the most common sequence. NMPO or cocaine use after marijuana, and heroin use after NMPO or cocaine, differed by generation. Among successively younger generations, NMPO after marijuana and heroin after NMPO increased. Millennials were more likely to initiate NMPO than cocaine after marijuana; Generation X and Baby Boomers were less likely (odds ratios = 1.4;0.3;0.2). Millennials were more likely than Generation X and Baby Boomers... Read More

Community-by-community, residents of Massachusetts are deciding if they want to be able to drive to the corner store to buy marijuana.

NIH’s 2017 Monitoring the Future survey shows both vaping and marijuana are more popular than traditional cigarettes or pain reliever misuse

He is no longer employed by Amtrak. No amount of marijuana use by an engineer is acceptable, the railroad has said.

there is incomplete evidence of the efficacy and safety of medical use of cannabis in the clinical contexts considered in this review. Furthermore, for many of the outcomes considered, the confidence in the estimate of the effect was again low or very low. To give conclusive answers to the efficacy and safety of cannabis used for medical purposes in the clinical contexts considered, further studies are needed, with higher quality, larger sample sizes, and possibly using the same diagnostic... Read More

“My job is to represent the people of Jacksonville Beach and as I mentioned during the council meeting, 81 percent of the people may have voted for medical marijuana. But it wasn’t 81 percent of Jacksonville Beach residents looking to put a dispensary in Jacksonville Beach,” Mayor Charlie Latham said.
#NotInMyBackyard

The overlapping endocannabinoid and endogenous opioid systems may explain this patient's response to therapy, and this synergistic relationship is discussed.
The endocannabinoid and endogenous opioid systems are syngergistic, which may explain the effect of naloxone in cannabis toxicity. Cannabinoid and opioid receptors belong to the rhodopsin subfamily of G-protein-coupled receptors which, when activated, reduce cellular levels of cyclic adenosine monophosphate (cAMP) by inhibiting... Read More

The number of drivers involved in fatal crashes in Colorado who tested positive for marijuana has risen sharply each year since 2013, more than doubling in that time, federal and state data show. A Denver Post analysis of the data and coroner reports provides the most comprehensive look yet into whether roads in the state have become more dangerous since the drug’s legalization.

Council members cite lack of local control as reason. The city of Venice will ban medical marijuana dispensaries within city limits, because current state statutes do not allow any form of local regulation above those placed on pharmacies. 
In moving toward prohibiting dispensaries, Venice joins the city of Sarasota and town of Longboat Key, though Sarasota is looking to modify its approach that would treat dispensaries the same as stand-alone pharmacies.