study

Conclusions and relevance: This study suggests that prenatal cannabis exposure and its correlated factors are associated with greater risk for psychopathology during middle childhood. Cannabis use during pregnancy should be discouraged.     

Findings  This meta-analysis of 20 studies of 1459 individuals found a significant pain reduction in response to placebo in cannabinoid randomized clinical trials. Media attention was proportionally high, with a strong positive bias, yet not associated with the clinical outcomes.
Meaning  These findings suggest that placebo has a significant association with pain reduction as seen in cannabinoid clinical trials, and the positive media attention may shape placebo responses in future trials.

Associations of Cannabis Use across Adolescence and Early Adulthood With Health and Psychosocial Adjustment in Early Adulthood and Midadulthood in Men
Results: Whereas there was almost no prediction from prior cannabis use to the physical health outcomes, there were comprehensive associations of cannabis use from the prior developmental period and psychosocial outcomes in both early adulthood and midadulthood.
Conclusion: Cannabis use in prior developmental periods was associated with a broad range of types of poor psychosocial adjustment in adulthood.

• A new study shows that using cannabis products to treat pain, anxiety and depression failed to improve these symptoms while doubling the risk of developing the addictive symptoms of cannabis use disorder.
• People seeking cannabis to treat symptoms of anxiety and depression were at greatest risk of CUD.
• Contrary to evidence-based medicine, people with medical marijuana cards choose their own products and dosing, suggesting the need for better controls over dispensing, use, and professional follow-up of these patients.

The study found that a number of brain disorders and behaviors predicted accelerated aging, especially schizophrenia, which showed an average of 4 years of premature aging, cannabis abuse (2.8 years of accelerated aging), bipolar disorder (1.6 years accelerated aging), ADHD (1.4 years accelerated aging) and alcohol abuse (0.6 years accelerated aging). Interestingly, the researchers did not observe accelerated aging in depression and aging, which they hypothesize may be due to different types of brain patterns for these disorders.

When mothers use marijuana during the first 12 years of their child's life, their cannabis-using children are more likely to start at an earlier age than children of non-using mothers, according to a new study from the Harvard T.H. Chan School of Public Health published in the American Journal of Preventive Medicine. This study is the first to establish a relationship between maternal cannabis use during a child's lifetime and earlier initiation in a nationally-representative, longitudinal cohort and examine the role of race, gender, and other social environmental factors.

We found that among young recreational cannabis users, a regular dose of cannabis had no effect on simple and learned tasks, but its use led to significant impairments on complex and novel driving-related tasks, as well as perceived driving ability and safety, for up to 5 hours after use. The present finding that the first 5 hours after cannabis use affected driving-related performance substantiates the recommendations of Canada’s Lower-Risk Cannabis Use Guidelines, which recommend waiting 6 hours after cannabis use before driving.30
 

Conclusions: Our findings disconfirm the hypothesis that a population-level negative correlation between medical marijuana use and prescription drug harms occurs because medical marijuana users are less likely to use prescription drugs, either medically or nonmedically. Medical marijuana users should be a target population in efforts to combat nonmedical prescription drug use.

Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency.
Cryptococcal meningitis is a life-threatening condition most commonly observed in immunocompromised individuals. We describe a daily cannabis smoker without evidence of immunodeficiency presenting with confirmed Cryptococcus neoformans meningitis. An investigation of cannabis samples from the patient's preferred dispensary demonstrated contamination with several varieties of Cryptococcus, including C. neoformans, and other opportunistic fungi. These findings raise concern regarding the safety of dispensary-grade cannabis, even in immunocompetent users.

The main finding was that when rats were exposed to secondhand smoke from marijuana for one minute, their arteries became less efficient at carrying enough blood for at least 90 minutes, whereas similar exposure to secondhand smoke from tobacco caused impairment that fully recovered within 30 minutes (exposure to clean air in the exposure chamber did not cause impairment). (It is important to understand that arteries of rats and humans are similar in how they respond to tobacco smoke, so the response of rat arteries to marijuana smoke is expected to be a valid indication of how human arteries respond to marijuana smoke.)

Abstract

Contemporary models of substance use disorders emphasize the role of cognitive control, which has been linked to difficulties in resisting the use of substances. In the present study, we measured two aspects of cognitive control, response inhibition (operationalized by a Go/NoGo Task) and performance monitoring (operationalized by an Eriksen Flanker Task), in a group of young cannabis-use disorder (CUD) patients and compared these functions with two control groups (i.e. a group of cigarette smokers and a group of non-smokers). We employed both behavioural and electrophysiological measures. The results indicate that CUD patients displayed reduced NoGo-P3 event-related potentials compared with non-smoking controls, but not compared with smoking controls. In addition, CUD patients were slower on Go trials than both control groups. No other between-group electrophysiological or behavioural differences were observed. These results seem to suggest that CUD patients have problems related to response inhibition, but performance monitoring seems relatively unaffected.

In the new study, researchers analyzed data from the Avon Longitudinal Study of Parents and Children, a long-running study in the U.K. that has followed women and their children. The study began when the women were first pregnant, all in 1991 or 1992.
For the new report, the researchers looked at questionnaires that more than 5,300 of the children completed. The kids were surveyed at least three times between ages 13 and 18, and asked about the frequency of their use of drugs, alcohol and tobacco in the previous three months. They were also sent a follow-up survey by mail to measure these behaviors at age 21.
Researchers found that teenagers in the study who regularly used marijuana were 26 times more likely to have used other illegal drugs, such as cocaine, amphetamines or hallucinogens, by the time they reached early adulthood, compared with teens who hadn't smoked pot, according to the findings published online today (June 7) in the Journal of Epidemiology and Community Health.

UC Davis physician researchers have found that medical marijuana contains multiple bacterial and fungal pathogens that may cause serious and even fatal infections. They warn that smoking, vaping or inhaling aerosolized marijuana could pose a grave risk to patients, especially those with leukemia, lymphoma, AIDS or conditions requiring immune-suppressing therapies.
 
“Infection with the pathogens we found in medical marijuana could lead to serious illness and even death,” said Joseph Tuscano, a professor of internal medicine in the Division of Hematology and Oncology at UC Davis, and a lead study author. “Inhaling marijuana in any form provides a direct portal of entry deep into the lungs where infection can easily take hold.”