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Largest brain study of 62,454 scans identifies drivers of brain aging study, Brain, aging, science daily

The study found that a number of brain disorders and behaviors predicted accelerated aging, especially schizophrenia, which showed an average of 4 years of premature aging, cannabis abuse (2.8 years of accelerated aging), bipolar disorder (1.6 years accelerated aging), ADHD (1.4 years accelerated aging) and alcohol abuse (0.6 years accelerated aging). Interestingly, the researchers did not observe accelerated aging in depression and aging, which they hypothesize may be due to different types of brain patterns for these disorders.

Daily Marijuana Use And Highly Potent Weed Linked To Psychosis study, Potency, Lancet, Psychosis

The study authors consider high-potency cannabis to be products with more than 10 percent tetrahydrocannabinol or THC, the compound responsible for the drug's psychoactive effects. The fact that consuming high-THC cannabis products has a greater risk is concerning, Lisdahl says, because these products are more common in the market now.

Now a new study published Tuesday in the The Lancet Psychiatry shows that consuming pot on a daily basis and especially using high-potency cannabis increases the odds of having a psychotic episode later.

cannabis use to variation in the incidence of psychotic disorder across Europe Research, study, Lancet, Potency, Psychosis

In conclusion, our findings confirm previous evidence of the harmful effect on mental health of daily use of cannabis, especially of high-potency types. Importantly, they indicate for the first time how cannabis use affects the incidence of psychotic disorder. Therefore, it is of public health importance to acknowledge alongside the potential medicinal properties of some cannabis constituents the potential adverse effects that are associated with daily cannabis use, especially of high-potency varieties.

Children of mothers Children, parents, study

When mothers use marijuana during the first 12 years of their child's life, their cannabis-using children are more likely to start at an earlier age than children of non-using mothers, according to a new study from the Harvard T.H. Chan School of Public Health published in the American Journal of Preventive Medicine. This study is the first to establish a relationship between maternal cannabis use during a child's lifetime and earlier initiation in a nationally-representative, longitudinal cohort and examine the role of race, gender, and other social environmental factors.

4-year prospective cohort study Lancet, study, pain

In conclusion, cannabis use is common in people with chronic non-cancer pain who have been prescribed opioids, and interest in medicinal use of cannabis is increasing. We found no evidence that cannabis use improved patient outcomes; those who used cannabis had greater pain and lower self-efficacy in managing pain. Furthermore, we found no evidence that cannabis use reduced pain interference or exerted an opioidsparing effect.

Cannabis use and driving-related performance Canada, Research, study, driving, youth

We found that among young recreational cannabis users, a regular dose of cannabis had no effect on simple and learned tasks, but its use led to significant impairments on complex and novel driving-related tasks, as well as perceived driving ability and safety, for up to 5 hours after use. The present finding that the first 5 hours after cannabis use affected driving-related performance substantiates the recommendations of Canada’s Lower-Risk Cannabis Use Guidelines, which recommend waiting 6 hours after cannabis use before driving.30
 

Study shows prenatal cannabis use associated with low birth weights Pregnancy, study

They also discovered that prenatal marijuana use was associated with a 50 percent increased chance of low birth weight regardless of tobacco use during pregnancy. “Growing evidence suggests prenatal cannabis exposure has a detrimental impact on offspring brain function starting in the toddler years, specifically issues related to attention deficit disorder,” Crume said. “But much of the research on the effects of prenatal cannabis on neonatal outcomes was based on marijuana exposures in the 1980s and 1990s which may not reflect the potency of today’s cannabis or the many ways it is used.”

 

Medical Marijuana Users are More Likely to Use Prescription Drugs Medically and Nonmedically opioid, study, Research

Conclusions: Our findings disconfirm the hypothesis that a population-level negative correlation between medical marijuana use and prescription drug harms occurs because medical marijuana users are less likely to use prescription drugs, either medically or nonmedically. Medical marijuana users should be a target population in efforts to combat nonmedical prescription drug use.

Pathway to Heroin heroin, addiction, study

Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency. Cryptococcal meningitis, chronic, study, PubMed

Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency.
Cryptococcal meningitis is a life-threatening condition most commonly observed in immunocompromised individuals. We describe a daily cannabis smoker without evidence of immunodeficiency presenting with confirmed Cryptococcus neoformans meningitis. An investigation of cannabis samples from the patient's preferred dispensary demonstrated contamination with several varieties of Cryptococcus, including C. neoformans, and other opportunistic fungi. These findings raise concern regarding the safety of dispensary-grade cannabis, even in immunocompetent users.

Systematic review of safeness and therapeutic efficacy of cannabis study, 'medicine', MS, Chemo

there is incomplete evidence of the efficacy and safety of medical use of cannabis in the clinical contexts considered in this review. Furthermore, for many of the outcomes considered, the confidence in the estimate of the effect was again low or very low. To give conclusive answers to the efficacy and safety of cannabis used for medical purposes in the clinical contexts considered, further studies are needed, with higher quality, larger sample sizes, and possibly using the same diagnostic tools for evaluating outcomes of interest.

Secondhand Pot Smoke Just As Bad For Heart As Tobacco study, second hand smoke

The main finding was that when rats were exposed to secondhand smoke from marijuana for one minute, their arteries became less efficient at carrying enough blood for at least 90 minutes, whereas similar exposure to secondhand smoke from tobacco caused impairment that fully recovered within 30 minutes (exposure to clean air in the exposure chamber did not cause impairment). (It is important to understand that arteries of rats and humans are similar in how they respond to tobacco smoke, so the response of rat arteries to marijuana smoke is expected to be a valid indication of how human arteries respond to marijuana smoke.)

Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review Veterans, opioid, study

"We found no observational studies that met inclusion criteria, but a growing body of cross-sectional literature suggests negative opioid-related correlates among individuals who use cannabis and opioids concurrently. These include opioid misuse;9,10,99,133 a greater number of opioid refills;99 a longer duration of opioid use; a higher dose of opioid medication prescribed;9 and endorsement of using opioids and other pain medications without a prescription.134"

Cognitive control in young adults with cannabis use disorder: An event-related brain potential study. CUD, Cannabis-use disorder, study

Abstract

Contemporary models of substance use disorders emphasize the role of cognitive control, which has been linked to difficulties in resisting the use of substances. In the present study, we measured two aspects of cognitive control, response inhibition (operationalized by a Go/NoGo Task) and performance monitoring (operationalized by an Eriksen Flanker Task), in a group of young cannabis-use disorder (CUD) patients and compared these functions with two control groups (i.e. a group of cigarette smokers and a group of non-smokers). We employed both behavioural and electrophysiological measures. The results indicate that CUD patients displayed reduced NoGo-P3 event-related potentials compared with non-smoking controls, but not compared with smoking controls. In addition, CUD patients were slower on Go trials than both control groups. No other between-group electrophysiological or behavioural differences were observed. These results seem to suggest that CUD patients have problems related to response inhibition, but performance monitoring seems relatively unaffected.

 

School Of Public Health Study Finds Use Of Marijuana Increases Risk Of Metabolic Syndrome School Of Public Health Study Finds Use Of Marijuana Increases Risk Of Metabolic Syndrome study, Georgia State University, Metabolic Syndrome

“Duration of marijuana use seems to be a significant factor associated with metabolic syndrome,” the researchers said.
Metabolic syndrome is a cluster of symptoms that increase a person’s risk for heart disease, stroke and diabetes.
The study found that “every year increase in marijuana use is associated with at least a 5 percent increase in odds of having metabolic syndrome.”

Teen Pot Use Linked to Illegal Drug Use by Age 21, Study Suggests study, longitudinal, UK, gateway

In the new study, researchers analyzed data from the Avon Longitudinal Study of Parents and Children, a long-running study in the U.K. that has followed women and their children. The study began when the women were first pregnant, all in 1991 or 1992.
For the new report, the researchers looked at questionnaires that more than 5,300 of the children completed. The kids were surveyed at least three times between ages 13 and 18, and asked about the frequency of their use of drugs, alcohol and tobacco in the previous three monthsThey were also sent a follow-up survey by mail to measure these behaviors at age 21.
Researchers found that teenagers in the study who regularly used marijuana were 26 times more likely to have used other illegal drugs, such as cocaine, amphetamines or hallucinogens, by the time they reached early adulthood, compared with teens who hadn't smoked pot, according to the findings published online today (June 7) in the Journal of Epidemiology and Community Health.

Patterns of cannabis use during adolescence and their association with harmful substance use behaviour: findings from a UK birth cohort study, longitudinal, PubMed

Conclusions One-fifth of the adolescents in our sample followed a pattern of occasional or regular cannabis use, and these young people were more likely to progress to harmful substance use behaviors in early adulthood.

Medical marijuana: Fungal, bacterial contaminants found, dangerous for immunocompromised patients contaminated, UC Davis, study

UC Davis physician researchers have found that medical marijuana contains multiple bacterial and fungal pathogens that may cause serious and even fatal infections. They warn that smoking, vaping or inhaling aerosolized marijuana could pose a grave risk to patients, especially those with leukemia, lymphoma, AIDS or conditions requiring immune-suppressing therapies.
 
“Infection with the pathogens we found in medical marijuana could lead to serious illness and even death,” said Joseph Tuscano, a professor of internal medicine in the Division of Hematology and Oncology at UC Davis, and a lead study author. “Inhaling marijuana in any form provides a direct portal of entry deep into the lungs where infection can easily take hold.”

Health Effects of Marijuana and Cannabis mental health, smoking, study, science engineering medicine, 2019 legislation

The evidence reviewed by the committee suggests that cannabis use is likely to increase the risk of developing schizophrenia, other psychoses, and social anxiety disorders, and to a lesser extent depression.   Heavy cannabis users are more likely to report thoughts of suicide than non-users, and in individuals with bipolar disorder, near-daily cannabis users show increased symptoms of the disorder than non-users.

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