meta-analysis

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Cannabinoids for Medical Use A Systematic Review and Meta-analysis 06/20/2015	A systematic review of the benefits and adverse events (AEs) A total of 79 trials (6462 participants) were included; 4 were judged at low risk of bias. Most trials showed improvement in symptoms associated with cannabinoids but these associations did not reach statistical significance in all trials. Data about AEs were reported in 62 studies (127 reports). There was an increased risk of short-term AEs with cannabinoids, including serious AEs. Common AEs included dizziness, dry mouth, nausea, fatigue, somnolence, euphoria, vomiting, disorientation, drowsiness, confusion, loss of balance, and hallucination. Four (5%) trials were judged at low risk of bias, 55 (70%) were judged at high risk of bias, and 20 (25%) at unclear risk of bias (eAppendix 13 in Supplement 2) The major potential source of bias in the trials was incomplete outcome data. More than 50% of trials reported substantial withdrawals and did not adequately account for this in the analysis. Common AEs included asthenia, balance problems, confusion, dizziness, disorientation, diarrhea, euphoria, drowsiness, dry mouth, fatigue, hallucination, nausea, somnolence, and vomiting. There was no clear evidence for a difference in association (either beneficial or harmful) based on type of cannabinoids or mode of administration. Only 2 studies evaluated cannabis. There was no evidence that the effects of cannabis differed from other cannabinoids. An additional limitation of many included studies was their very small sample sizes. Future studies should assess patient-relevant outcomes (including disease-specific end points, quality of life, and AEs) using standardized outcome measures at similar time points to ensure inclusion in future meta-analyses. Future trials should adhere to the CONSORT (Consolidated Standards of Reporting Trials) reporting standards197 and ensure that appropriate methods are used for randomization, allocation concealment, patient and outcome assessor blinding, handling of withdrawals, and avoiding selective outcome reporting. meta-analysis, Research, 2017 Legislation
Association Between the Use of Cannabis and Physical Violence in Youths: A Meta-Analytical Investigation 06/01/2020	After screening 11,348 potential studies....These results demonstrate a moderate association between cannabis use and physical violence, which remained significant regardless of study design and adjustment for confounding factors (i.e., socioeconomic factors, other substance use). Cannabis use in this population is a risk factor for violence. meta-analysis, Research
Association Between Electronic Cigarette Use and Marijuana Use Among Adolescents and Young Adults 08/12/2019	Conclusions and Relevance This meta-analysis found a significant increase in the odds of past or current and subsequent marijuana use in adolescents and young adults who used e-cigarettes. These findings highlight the importance of addressing the rapid increases in e-cigarette use among youths as a means to help limit marijuana use in this population. meta-analysis
Marijuana use and physical dating violence among adolescents and emerging adults: A systematic review and meta-analysis. 03/18/2017	Findings suggest that marijuana use is associated with a 54% increase in the odds PDV (physical dating violence) victimization, and a 45% increase in the odds of perpetration. CONCLUSIONS: Findings suggest that dating violence is a correlate of marijuana use, and that association is strongest among adolescents (vs. emerging adults) and girls (vs. boys). meta-analysis, PDV, adolescent, Studies, Research, ncbi
Medical Marijuana for Pain: What the Evidence Shows 08/19/2015	Twenty-eight studies were undertaken to evaluate the effectiveness of cannabinoids for chronic pain. Of these, only 2 were found to be at low risk of bias. Overall, these studies seem to indicate that cannabinoids have a significant role to play in the management of chronic pain. However, there are important issues that limit the validity of this conclusion. First and most important is how the improvement in pain was evaluated. In many of the studies, only instruments to measure the level of pain, most notably the Visual Analogue Scale, were used. This is fine when one is measuring acute pain. But when it comes to chronic pain—which is what the studies were looking at—the most important measures of the impact of any treatment are improvement in functioning and other objective measures, such as reduction in use of analgesic medications. meta-analysis, Studies, Placebo, pain
HABITUAL MARIJUANA USE AND THE PALEO DIET: WHAT A LONG STRANGE TRIP IT’S BEEN 01/28/2015	PDF format Paleo, health, meta-analysis, Studies
Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis 12/11/2012	Acute cannabis consumption is associated with an increased risk of a motor vehicle crash, especially for fatal collisions. This information could be used as the basis for campaigns against drug impaired driving, developing regional or national policies to control acute drug use while driving, and raising public awareness. Studies, Research, car crashes, meta-analysis, Fatalities