heredity

Current sort has key articles at the top. Click on "Article Date" to sort by date, click on specific "tag" to view all articles in that category.

Title
Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring
11/20/2022

Conclusions: This is the first characterization of the effect of cannabis exposure on the entirety of the rat sperm methylome. We identified CE-associated methylation changes across the sperm methylome, some of which persisted despite a "washout" period. Select methylation changes validated via bisulfite pyrosequencing, and genes associated with methylation changes were involved in early developmental processes. Preconception CE exposure is associated with detectable changes in offspring DNA methylation that are functionally related to changes in gene expression and cardiomegaly. These results support that paternal preconception exposure to cannabis can influence offspring outcomes.     


study, Research, rats, offspring, heredity, 2023 Presentation Dr Berry
Subscribe to heredity