Thus, adolescent THC exposure induced behavioral abnormalities resembling positive and negative schizophrenia-related endophenotypes and a state of neuronal hyperactivity in the mesocorticolimbic dopamine (DA) pathway. Furthermore, we observed profound alterations in several prefrontal cortical molecular pathways consistent with sub-cortical DAergic dysregulation. Our findings demonstrate a profound dissociation in relative risk profiles for adolescent versus adulthood exposure to THC in terms of neuronal, behavioral, and molecular markers resembling neuropsychiatric pathology.
Links
[1] http://cercor.oxfordjournals.org/content/early/2016/01/04/cercor.bhv335.abst
[2] http://rethinkpot.org/tags/brain
[3] http://rethinkpot.org/tags/adolescent
[4] http://rethinkpot.org/tags/research