Prepare for Patients Using Concentrated 7‑OH Products

7-hydroxymitragynine (7-OH) is a naturally occurring alkaloid found in trace amounts in the kratom plant. It is now being concentrated and sold in commercial products. Although kratom can produce a range of effects and regular use may lead to dependence and withdrawal, concentrated 7-OH can produce more potent opioid effects. These effects – including respiratory depression, dependence, withdrawal, and overdose risk – are the primary clinical concern.